The Synthesis and characterization of Mn and Co (II) complexes with tetradentate N2O2 donor Schiff Base: interaction with human serum albumin (HSA) with Mn(II) complex and antibacterial activity
A tetra coordinated manganese(II) and cobalt (II) complexes formulated as [Mn(L] (1) and [Co(L)](2) H2L = 2,2’-(4-nitro-1,2-phenylene)bis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)bis(4-nitrophenol)were synthesized and characterized by elemental, physico-chemical and spectroscopic methods. The four coordination spheres of metal (II) ions have been satisfied by two imine nitrogen- N and two phenolate oxygen-O donors of organic moiety (HL).The interactions of manganese (II) complex towards human serum albumin (HSA) was examined with the help of absorption spectroscopic tools. Antibacterial activity of complexes (1 and 2) studied by agar disc diffusion method with some pathogenic bacteria namely Escherichia coli, Vibrio cholerae, Streptococcus pneumonia and Bacillus cereus.
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